ABSTRACT
Objective: To evaluate the role of sub anesthetic dose of ketamine when given 5 minutes prior to Propofol injection in alleviating pain of injection during cesarean section surgery
Study Design: Randomized controlled trial
Place and Duration of Study: Department of anesthesia and critical care, Nishtar Hospital Multan, from Aug 2016 to Feb 2017
Material and MethodsA total number of 130 [100 percent] patients were included in the study. Data was analyzed using SPSS [v 23.2], mean and SD calculated for continuous data [age, BMI] and in continuous data was presented as frequency and percentages [ASA status, pain of propofol injection]. Effect modification seen by applying chi square test and p-value
Results: A total number of 100 percent [n=130] patients were included in this study, all were females. The main outcome variable of this study was pain of propofol injection. It was observed that, in control group, 87.7 percent [n=57] patients complaints about pain after propofol injection and 12.13 percent [n=8] remain normal. But, in ketamine group only 16.9 percent [n=11] patients complaint about pain of propofol injection and 83.1 percent [n=54] were remained pain free
Conclusion: Administration of ketamine 0.25Ug/kg five minutes before propofol injection is a safe and effective method in preventing propofol injection pain